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Nagarjuna's Content

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#165613 How to control the pH of water after sterilization ?

Posted by Nagarjuna on 28 February 2014 - 08:43 AM in Pharmacology and Pharmaceutics

Dear Forum members,


I want to formulate a parenteral preparation whose pH should be between 10.5 to 11.10;

Here medium is water, the pH of the water adjusted to 11.00 with 0.1N NOH solution, after sterilization the pH decresed to 7.5, why so ?

Without teriziation pH of water is decreasing to 10.5.

Is any alternate is there to maintain the pH (even after sterilization) ?

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