Dear Forum members,
I want to formulate a parenteral preparation whose pH should be between 10.5 to 11.10;
Here medium is water, the pH of the water adjusted to 11.00 with 0.1N NOH solution, after sterilization the pH decresed to 7.5, why so ?
Without teriziation pH of water is decreasing to 10.5.
Is any alternate is there to maintain the pH (even after sterilization) ?