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Can RNAi be used for silencing of non-coding RNAs? - (May/26/2008 )

I was just curious to know rolleyes.gif

-Papo Chulo-

QUOTE (Papo Chulo @ May 26 2008, 04:41 AM)
I was just curious to know rolleyes.gif

'm curious too. angry.gif

-cellcounter-

Yes.

Since the siRNA target any rna, you could knockdown non-coding RNAs.

-Madrius-

Yes, it is possible. Check this paper Specific and potent RNAi in the nucleus of human cells

-pcrman-

Great! Thanks. I'm doing this theoretical laboratory project where I have to target human telomerase as a cancer therapy. TERC, prepare for silencing ph34r.gif

-Papo Chulo-

QUOTE (Papo Chulo @ May 26 2008, 12:01 PM)
Great! Thanks. I'm doing this theoretical laboratory project where I have to target human telomerase as a cancer therapy. TERC, prepare for silencing ph34r.gif

Theoretical? biggrin.gif You will be a great PI tongue.gif

-cellcounter-