CNS injury - (Dec/12/2006 )

Good of you Pumuki!Anyway, thanks for the link. Appreciate your time and contribution. Have a nice day with animals, i have bad experience with animals before,but now it quite better for good.haha

Good luck with your animals

Possibly other bioforumers will post more ideas

If u could clamp carotid arteries briefly on both sides, this should induce ischemia globally, and globus pallidus (basal ganglia) would be the first area to be affected.

but if u r thinking of specifically, targetting putamen or caudate nucleus, it might b more tricky.

To b honest, I would not even attempt MCAO model, as I have seen that it gives quite variable lesions animal to animal.


Well, Good Luck !!!

Scolix,thanks for the ideas,but sorry to ask this stupid question : why globus palidus first to be affected when clipping those arteries?Are there were any explanation on this?curious..

No question is stupid, so dont worry abt asking questions.

Globus pallidus bcoz, it is a water shed area between 2 cerebral arteries. When u have ischemia, the watershed areas are the ones which r affected initially.

ok,you satisfied me. But then, still need to find the good model for basal ganglia trauma model. Back then,can i just stab the needles stereotaxically correct to the globus pallidus as my basal ganglia trauma model? Or do i need to follow any model available in the literature? there"s must be a way out.. now i'd appreciate what my BOSS said this is what really called 're-search'. OMG. so, what should i do?