Protein Full Names - (Jun/01/2006 )
What does the abbreviation of Akt, Src, Syk mean.
Google says Src, Syk and Akt are all families of protein kinases.
As the other said they are all proteins kinases.
Akt is also known as Protein kinase B (PKB) and is downstream of PI3 kinase.
Syk is downstream of the B-cell receptor and Src is involved in several pathways (receptor tyrosine kinases, TCR etc.)
Sorry you asked what the abbreviations stood for:-
Spleen tyrosine kinase (Syk)
Not sure about Akt. Sometimes as protein kinases are oncogenes it's taken from the cancer they were first identified it. I think it stands for AKT8-induced thymoma possibly because it was isolated from an oncogenic retrovirus which caused thymomas?
Proc Natl Acad Sci U S A. 1987 Jul;84(14):5034-7. Related Articles, Links
Molecular cloning of the akt oncogene and its human homologues AKT1 and AKT2: amplification of AKT1 in a primary human gastric adenocarcinoma.
A previous report described the isolation of a directly transforming retrovirus, AKT8, from a spontaneous thymoma of an AKR mouse. The AKT8 provirus has now been molecularly cloned from a transformed, nonproducer cell line. The virus genome contains both viral and nonviral, cell-related sequences; the nonviral sequence has been designated v-akt, the presumed viral oncogene of the AKT8 virus. This gene lacks homology to the 16 other oncogenes tested. The cloned provirus has undergone a partial deletion, during cell passage in vitro, that prevents direct demonstration of the transforming ability of this molecular clone. Two human homologues of the v-akt oncogene, AKT1 and AKT2, were cloned. A survey of 225 human tumors for changes involving AKT1 led to the discovery of a 20-fold amplification of this gene in one of the five gastric adenocarcinomas tested. The results demonstrate that AKT8 has the characteristic structure of a directly transforming retrovirus and that it contains a gene derived from highly conserved cellular sequences that may be involved in the pathogenesis of some human malignancies.
All the best,