DNA Repair in different cells - (Sep/29/2005 )
Does anyone know whether DNA Repair should be the same in different cell types. For example if I treat an epithelial cell with a damaging agent should I expect to get the same result for a fibroblast?
JM
-jmachado-
QUOTE (jmachado @ Sep 30 2005, 03:46 AM)
Does anyone know whether DNA Repair should be the same in different cell types. For example if I treat an epithelial cell with a damaging agent should I expect to get the same result for a fibroblast?
JM
JM
It depends on the basal gene expresssion of different cell types. For example, some cell types might have a lower expression or absence of certain DNA repair genes, some cell types shows more resistance to damaging agents.
Even different concentration of DNA damaging agents might cause different degrees of DNA damage
-kia-
QUOTE (kia @ Sep 30 2005, 04:50 AM)
QUOTE (jmachado @ Sep 30 2005, 03:46 AM)
Does anyone know whether DNA Repair should be the same in different cell types. For example if I treat an epithelial cell with a damaging agent should I expect to get the same result for a fibroblast?
JM
It depends on the basal gene expresssion of different cell types. For example, some cell types might have a lower expression or absence of certain DNA repair genes, some cell types shows more resistance to damaging agents.
Even different concentration of DNA damaging agents might cause different degrees of DNA damage
And even different phases of the cell-cycle will give different repair patterns
-Theo22-