Advice for a Clinician - Calprotectin - the details (Mar/09/2005 )
I'm a paediatric gastroenterologist and starting PhD research into inflammatory states affecting children and a specific interest into Calprotectin and its application as a marker of inflammation in the gut (inflammatory bowel disease, gut permeability, food allergies, etc.).
'Purely' medical journals explain basic information on the validity of this molecule as an aid to test the presence or absence of disease in the gut.
However since I am a clinician, it is rather hard to find comprehensive information about this molecule's structure, its origins, its specific inter/actions and effects. I would be very grateful indeed if someone could point me in the right direction. Non-clinical literature searches have yielded alot of very detailed information that is confusing at best! Does a map of pathway/s exist? Is there just one chemical name for this molecule or do more exist?
I would be very happy indeed to read from anyone who could help me in this endeavour.
Please check HPRD
Its a database of Human proteins and has comprehensive information about calprotectin. You could query the protein by its name.
The database will provide information about Alternative names, PTMs, Interactions and the likes with relevant literature evidence. Also it has links to major public databases like NCBI, SWISSPROT, etc along with the accession numbers of the protein.
Hope this is helpful, and streamlines your search.
will check it out now.
Fantastic, thank you for that link - it is a great help. The problem with us clinicians is that we lose sight of the basic building blocks and just look at the whole patient.
If you can suggest a source of information where I can see a pathway map of how white cells interact with each other and sites of inflammation - cell signalling - which mediators evoke which response - I would be grateful.
You are welcome.
It has a list of all pathways and you could check for the pathway you are specifically looking for. It also has an ftp site from where you can download all the information.