Are all these arrows equally trusted?! - (Sep/10/2008 )
I have been puzzled with the signaling pathways. Every time I print a map, I wander from where to read right to left or up-down or diagonal but in all cases I ask myself are all these lines, arrows or edges trusted or equally trusted?!
So, the only conclusion that can be concluded from these maps is that.... our body is very complicated?!! Targeting one protein may bring everything upside down. So, just try and see what will happen, but do not try to understand … a difficult unnecessary job.
Do you agree 
-MolBio79-
QUOTE (MolBio79 @ Sep 10 2008, 12:26 AM)
I have been puzzled with the signaling pathways. Every time I print a map, I wander from where to read right to left or up-down or diagonal but in all cases I ask myself are all these lines, arrows or edges trusted or equally trusted?!
So, the only conclusion that can be concluded from these maps is that.... our body is very complicated?!! Targeting one protein may bring everything upside down. So, just try and see what will happen, but do not try to understand … a difficult unnecessary job.
Do you agree
So, the only conclusion that can be concluded from these maps is that.... our body is very complicated?!! Targeting one protein may bring everything upside down. So, just try and see what will happen, but do not try to understand … a difficult unnecessary job.
Do you agree
I do agree with you....they say Bcl-2 level decreases during apoptosis, but we are observing increase in our experiments. it is just too complicated....it is like all these proteins interact with each other at some points. I honestly don't believe that one protein only interasts with its complementary protein. They all have effect on each other.
-Curtis-
QUOTE (MolBio79 @ Sep 10 2008, 01:26 AM)
I have been puzzled with the signaling pathways. Every time I print a map, I wander from where to read right to left or up-down or diagonal but in all cases I ask myself are all these lines, arrows or edges trusted or equally trusted?!
So, the only conclusion that can be concluded from these maps is that.... our body is very complicated?!! Targeting one protein may bring everything upside down. So, just try and see what will happen, but do not try to understand … a difficult unnecessary job.
Do you agree
So, the only conclusion that can be concluded from these maps is that.... our body is very complicated?!! Targeting one protein may bring everything upside down. So, just try and see what will happen, but do not try to understand … a difficult unnecessary job.
Do you agree
If these arrows are used in a schematic, then where are the kinetic rate constants to go with them ?
-Rhombus-
QUOTE (Rhombus @ Sep 10 2008, 08:27 PM)
If these arrows are used in a schematic, then where are the kinetic rate constants to go with them ?
This is a good point ... Rhombus
Also, in many signaling pathways you can click on the node (protein) to view something related to it e.g. in companies Ab, in others databases link to gene, structure, ... etc. but I wish to find a pathway database where I can click on the arrow (edge) to find at least what are the citation(s) used to draw this arrow.
Are not this useful ...
What are other things missing in the signaling pathways
-MolBio79-