How to identify whether a mutation in intron is binding site? - (Sep/04/2008 )

HI all, I have a problem to identify whether a deletion in intron is actually a transcriptor binding site? How to identify whether the mutation will give any impact to the transcription process of the gene? Thanks

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Look at the ensembl database and see if the area surrounding that gene has been flagged as a regulatory sequence. If not then the chance are that it's not.

There are other databases you could do this with but I can't think of any ATM.

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