Domperidone - (Aug/01/2008 )

Hi Bioforumers:
I need any information about the relation between domperidone and weight gain and loss during withdrawal period.
Thanks in advance

Hi,

As I know, domperidone is a metoclopramide analogue, but doesn't pass through hemahoencephalic barrier. So, i think there's no relation between this anti-emetic drug and the gain/loss of weight.

Sorry... i can't help more.

One of the side-effects of Domperidone is weight gain is clinically significan - patients have to be informed of this. I am not sure of the mechanism but it has something to do with Prolactin. Domeperidone causes rise in Prloactin level and that should be linked to weight gain. Beside weight gain, other unwanted effects of Prolactin can also be seen.

The mechanism of domperidone is the block of dopamine receptors in inhibitory neurons of stomach and duoden.
Like last post said, and i'm sorry for my first and wrong post, domperidone rises the libertation of prolactin by blocking the D2 receptors.
I don't know how, but it's true, there is a relation between weight gain and prolactin levels.

Domperidone (trade name Motilium, Motillium or Costi) is an antidopaminergic drug, developed by Janssen Pharmaceutica, and used orally, rectally or intravenously, generally to suppress nausea and vomiting. It has also been used to stimulate lactation.
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