Finding out what sequence to study by ChIP - (Jul/28/2008 )
Sorry but I really don't have time to be reading up about which histone modifications you should be studying. Do you have a supervisor or colleague working in a similiar area that you could ask?
The problem is my whole branch is not familiar with histone modifications and all information I have is from literature.
Other ppl in my branch are more interested in DNA methylation-chip
last week's Nature (454, p713), there's a very small table in a feature article:
Transcriptional "ON" : H3K9ac, H3K4me, H4K16ac
Transcriptional "OFF": H3K9me, H3K27me
but methylation can be mono-, di- or tri-.....
My impression is at the moment there's no definite model yet