Which Nitric Oxide Donor should I use - (Jul/13/2008 )
Hi all,
I'm working in the field of cardiovascular research, focusing on nitric oxide (NO) as a prophylactic/therapeutic drug.
I would like to treat rats with a conventional NO donor drug, then evaluate its cardioprotective effects and compare this with our novel test drug.
Some of the NO donors I'm looking at include SNP (sodium nitroprusside), SNAP and nicorandil.
However, I am unsure of which conventional NO donor would be the most suitable. What do you guys think? I'll love to have some feedback/opinions on this matter.
Some criteria/considerations of the drug include:
1. slow-release of NO ( as the effect of a fast-release NO donor will not be sustained)
2. administered by the intra-peritoneal route ( ease of administration)
3. conventional, well-established ( for comparison with our test drug)
I'll really appreciate if anyone working in this field could help me.
THanks alot!
I'm working in the field of cardiovascular research, focusing on nitric oxide (NO) as a prophylactic/therapeutic drug.
I would like to treat rats with a conventional NO donor drug, then evaluate its cardioprotective effects and compare this with our novel test drug.
Some of the NO donors I'm looking at include SNP (sodium nitroprusside), SNAP and nicorandil.
However, I am unsure of which conventional NO donor would be the most suitable. What do you guys think? I'll love to have some feedback/opinions on this matter.
Some criteria/considerations of the drug include:
1. slow-release of NO ( as the effect of a fast-release NO donor will not be sustained)
2. administered by the intra-peritoneal route ( ease of administration)
3. conventional, well-established ( for comparison with our test drug)
I'll really appreciate if anyone working in this field could help me.
THanks alot!
I don't really know which one you should use, but I do know that with SNAP you can induce ER-stress/Unfolded Protein Response and then almost everything is shut down in a cell and they will go into apoptosis. I don't know anything about the other inducers, but SNAP does give some (unwanted?) side effects.
I'm working in the field of cardiovascular research, focusing on nitric oxide (NO) as a prophylactic/therapeutic drug.
I would like to treat rats with a conventional NO donor drug, then evaluate its cardioprotective effects and compare this with our novel test drug.
Some of the NO donors I'm looking at include SNP (sodium nitroprusside), SNAP and nicorandil.
However, I am unsure of which conventional NO donor would be the most suitable. What do you guys think? I'll love to have some feedback/opinions on this matter.
Some criteria/considerations of the drug include:
1. slow-release of NO ( as the effect of a fast-release NO donor will not be sustained)
2. administered by the intra-peritoneal route ( ease of administration)
3. conventional, well-established ( for comparison with our test drug)
I'll really appreciate if anyone working in this field could help me.
THanks alot!
I don't really know which one you should use, but I do know that with SNAP you can induce ER-stress/Unfolded Protein Response and then almost everything is shut down in a cell and they will go into apoptosis. I don't know anything about the other inducers, but SNAP does give some (unwanted?) side effects.
How about Spermine NONOate. We gave it to Rats IP, and was was well tolerated. Not sure about the pharmacokinetics, though.