Protocol Online logo
Top : Forum Archives: : Genetics

help with SNPs - (Sep/05/2007 )

Please excuse my ignorance, but I am an anthropologist using SNPs for population study. I'm looking into the SNPs for Lactase, but am confused on how you determine which SNP corresponds to location of knonw allelic differences. For example, i'm looking into the allelic change -13910 T/C in european population in intron 13 od the MCM6 /LCT genes, but how does one determine which snp corresponds to this from the snp browser at NCBI ?

thanks a bunch
a

-abentley-

You might need to trawl through the original papers to see the populations tested (assuming such data is given...)

-swanny-

QUOTE (abentley @ Sep 5 2007, 03:03 PM)
Please excuse my ignorance, but I am an anthropologist using SNPs for population study. I'm looking into the SNPs for Lactase, but am confused on how you determine which SNP corresponds to location of knonw allelic differences. For example, i'm looking into the allelic change -13910 T/C in european population in intron 13 od the MCM6 /LCT genes, but how does one determine which snp corresponds to this from the snp browser at NCBI ?

thanks a bunch
a


I am new to this subject but did you have a look at the HapMap project?
Maybe this might help you:

The HapMap Project

-kylvalda-

thanks for all the advice. i've discovered that the SNP number correlates with the position on the chromosome and not the position on the suspect gene (as the latter is how it's usually described in papers and essays)...

-abentley-

hey i am also new to the field of genetics basically i am a biochemist.I have to study some SNPs for beta thalassemia.please excuse me for my ignorence i dont know how to chose and what method should i use for the study?I have studied some papers in which pepole have used microarrays and mass arrays for the same?is it possible to use PCR-RFLP or sequencing methods?

-vineeta-