4-Hydroxytamoxifen - 4-OHT activates Ras/Erk pathway (Jan/16/2007 )
hi,
It is said in a paper that 4-OHT activates Ras/ Erk pathway without affecting other signaling pathways. Have you ever used 4-OHT or have you ever heard about it?
I have done some search but could not find anything regarding the above information.
Thanks in advance. 
I have posted it in "cell biology products" forum but no replies:) Unfortunately, there were only 4 viewers of the topic 
-dodosko-
well ack during my cell cycle course, i hearded that Tamoxifen which was the drug my mother took for breast cancer, was an inhibitor of the TgfB receptor.
I may have a look at this point but i don't know further...
-fred_33-
QUOTE (dodosko @ Jan 16 2007, 01:49 PM)
hi,
It is said in a paper that 4-OHT activates Ras/ Erk pathway without affecting other signaling pathways. Have you ever used 4-OHT or have you ever heard about it?
I have done some search but could not find anything regarding the above information.
Thanks in advance.
I have posted it in "cell biology products" forum but no replies:) Unfortunately, there were only 4 viewers of the topic
It is said in a paper that 4-OHT activates Ras/ Erk pathway without affecting other signaling pathways. Have you ever used 4-OHT or have you ever heard about it?
I have done some search but could not find anything regarding the above information.
Thanks in advance.
I have posted it in "cell biology products" forum but no replies:) Unfortunately, there were only 4 viewers of the topic
we once constructed plasmids with hydroxytamoxifen inducible promotors...(now using doxycyclin activatable promotors)
tamoxifen binds competitively to estrogen receptors and has itself a 100-fold lower stimulatoty effect on estrogen receptor than estrogen
-The Bearer-