single channel and whole cell - (Dec/12/2006 )

i want to know what you interpret from single channel and whole cell recoding.

Single Channel Recording: When the pipette touches the cell membrane and forms a high resistance seal (~1GOhm), you are in the "cell attached" recording configuration. You do this before making the "whole cell" recording.

Whole Cell Recording: When you apply suction to the back of the pipette to break the cell membrane, you enter the "whole cell" recording mode. In this configuration the pipette solution and the cell interior become contiguous.

Thanks for such a nice explanation but i want to know what you explain from whole cell recording and which can not explain from single channel recording.