what is the inhibition mechanism of PLC by U73122? - (Sep/27/2006 )

How PLC- is inhibited? through binding the lipase domain? or block the assoction between lipase and substrate?

Thanks so much.

I remember to have read a paper when we used U73122 where about the mechanism was speculated:

www.jbc.org/cgi/reprint/267/20/13830.pdf