official database for cancer-related genes - (Jul/24/2006 )
Does anyone know an offcial database or a list for cancer-related genes? Any suggestion would be appreciated.
Try this link:
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=OMIM
If you select OMIM from the drop down menu and type "cancer", you should get a large number of hits. Each hit will specify the gene invloved in cancer.
Hope this helps
i like this one too...
http://www.infobiogen.fr/services/chromcancer/
Hi,
I think gene ontology information can be used.
First, go to advance search of godatabase
http://www.godatabase.org/cgi-bin/amigo/go...9179b1153778220
and type something like tumor to search in GO terms,
this will supposedly give some GO terms, and you should check the corresponding genes, this is not too much feasible, I admit...
However, I have a database where I merged gene information with ontologies, I searched the term "tumor" in molecular funciton field; 30 genes come with that:
A2M alpha-2-macroglobulin
FASLG Fas ligand (TNF superfamily, member 6)
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8
CD40LG CD40 ligand (TNF superfamily, member 5, hyper-IgM syndrome)
TNFSF7 tumor necrosis factor (ligand) superfamily, member 7
EDA ectodysplasin A
LTA lymphotoxin alpha (TNF superfamily, member 1)
LTB lymphotoxin beta (TNF superfamily, member 3)
TNF tumor necrosis factor (TNF superfamily, member 2)
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 (tax-transcriptionally activated glycoprotein 1, 34kDa)
TNFRSF4 tumor necrosis factor receptor superfamily, member 4
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9
TNFRSF14 tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator)
TNFRSF18 tumor necrosis factor receptor superfamily, member 18
TNFSF18 tumor necrosis factor (ligand) superfamily, member 18
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15
TRAP1 TNF receptor-associated protein 1
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b
ARTS-1 type 1 tumor necrosis factor receptor shedding aminopeptidase regulator
TNFRSF19 tumor necrosis factor receptor superfamily, member 19
EDA2R ectodysplasin A2 receptor
TNFSF12-TNFSF13 tumor necrosis factor (ligand) superfamily, member 12-member 13
when I searched in biological process with tumor; than 5 genes
AZU1 azurocidin 1 (cationic antimicrobial protein 37)
CD86 CD86 antigen (CD28 antigen ligand 2, B7-2 antigen)
SPN sialophorin (gpL115, leukosialin, CD43)
TLR1 toll-like receptor 1
IL17F interleukin 17F
you can increase the search by using some additional terms like proliferation, cancer, angiogenesis etc, although it will take some more time with GO search tools...
p.s: If you like the idea, I can make some further searches and put the list here...
ersen