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ampicillin trihydrate not dissolving - problem with ampicillin dissolving (Jul/23/2009 )

Hi all,

I am trying to dissolve ampicillin trihydrate in distilled water at a concentration of 50mg/ml.

I wanted to prepare 50ml of ampicillin solution. So I used 2.5gm of ampicillin to dissolve in distilled water.I made it upto 50 ml.

But I have difficulty dissolving it. It remains as a ilky white solution and after few mins I can see the precipitation.

Is there a solution for this?

Regards
MS

-miraclestrain-

miraclestrain on Jul 24 2009, 02:28 PM said:

Hi all,

I am trying to dissolve ampicillin trihydrate in distilled water at a concentration of 50mg/ml.

I wanted to prepare 50ml of ampicillin solution. So I used 2.5gm of ampicillin to dissolve in distilled water.I made it upto 50 ml.

But I have difficulty dissolving it. It remains as a ilky white solution and after few mins I can see the precipitation.

Is there a solution for this?

Regards
MS


Friend, your ampicillin trihydrate is only slightly soluble in water, and practically insoluble in alcohol and in fatty oils. It dissolves
in dilute solutions of acids and of alkali hydroxides. try a dilute NaOH solution like 0.1M or 1mM.

-chrisbelle-