heat maps - how to read/understand them (May/24/2009 )
Hi, Usually heatmaps are presented to show patterns of genes being regulated.
Can anyone suggest a website, book or paper which explains hows to read/understand a heat map. I have been asked to read on this topic. Each cells in a heat map represents the expresison of a gene and teh expression intensity is colour coded e.g. red for high expresison etc. But my main cincern is that when peope publish a heatmap, all teh reader see's a bock of red,yello and green colours. It doens
This means that showing each and every name would be very cumbersome, instead you show genes from a given pathway or with similar Gene Ontology (GO) terms.
So, as an example, if I would like to show that a given drug causes DNA damage in my cells I could look for genes in the p53 pathway and look at their expression pattern.
Usually heatmaps are presented to show patterns of genes being regulated.