drug admin. to mice with use of peanut butter? - seeking info (Apr/27/2009 )
TicTacToe on May 4 2009, 12:24 AM said:
SamOH on Apr 30 2009, 07:32 AM said:
Have you considered gavage?
Yes, actually I have suggested using gavage~
Apparently because our drug of interest has been used orally for other diseases, i think my boss wants to know its feasibility as an oral drug to treat our disease of interest. So in this case, serving it as food would be more realistic?
And he thought that probably using gavage might take up more time than with peanut butter~~because i haven't done gavage before.
In terms of preclinical assessments of the feasibility as an oral drug, anything that gets it into the stomach would be OK. Since most oral drugs are given to patients as a tablet/capsule (maybe as a fluid), one could argue that orogastric administration of the drug via gavage more closely mimics the expected/desired clinical dosing scenario.
If you give it to them in food they like (we've used nut paste) they should eat it in no time. You could probably just move them to a single housing for the feeding part, and then return them to their group housing. One trick though - mice are a bit neophobic so you should introduce the peanut butter a few days in advance (without the drug of course). Once they're used to it they'll eat it gladly in a matter of minutes (no fasting required)...
SatanClaus on Jun 11 2009, 01:06 PM said:
thank you all who have given suggestions~
i have commenced the drug feeding with peanut butter~
at the end i'm using a syringe to deposit the peanut butter and to control the dosing~
it was a little difficult controling the amount because the peanut butter is thick and it was a bit hard to inject out~
aside from the concern of homogeneity of the mixture...the feeding seemed ok so far~