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Signal peptide - (Mar/02/2009 )

Dear all:

Hi, we have found a protein that may involve in secretory pathways. By more than one experiments, we see that this protein shows a non-autonomous effect.

However, its sequence does not have a signal peptide.

The only possible hint is that this protien is in a complex and one of its interaction partner has a signal peptide.

Is it possible if this protein can be secreted together with its partner?
And how this is possible?

-johnny.jeng03-

johnny.jeng03 on Mar 2 2009, 11:41 PM said:

Dear all:

Hi, we have found a protein that may involve in secretory pathways. By more than one experiments, we see that this protein shows a non-autonomous effect.

However, its sequence does not have a signal peptide.

The only possible hint is that this protien is in a complex and one of its interaction partner has a signal peptide.

Is it possible if this protein can be secreted together with its partner?
And how this is possible?


Does it contain transmembrane domain?
You may not find a signal peptide in a membrane protein using computer programes.

-WHR-