Deletion and Insertion Allele - what are they? (Jan/27/2009 )
Came across these terms - but cannot find what they mean. Please, can anyone give me simple explanation.
Nabi on Jan 27 2009, 06:05 PM said:
I am unable to find the reply. Can anyone suggest me any site where I can make my self familiar with basic terminologies in molecular biology like 'deletion allele'
well it means what it says.
Some alleles of genes are dues to short DNA sequence insertion and deletions into an exon.
Google this paper for an example
A 45-bp Insertion/Deletion Polymorphism of Uncoupling Protein 2 in Relation to Obesity in Tongans
Thank U pernesblue. Had come across other papers telling about deletion alleles of ACE in Japanese also. Wish could understand. Will try fresh tomorrow.
I was trying to understand what it meant by deletion allele and wild type allele in knockout mice.