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Deletion and Insertion Allele - what are they? (Jan/27/2009 )

Came across these terms - but cannot find what they mean. Please, can anyone give me simple explanation.

-Nabi-

Nabi on Jan 27 2009, 06:05 PM said:

Came across these terms - but cannot find what they mean. Please, can anyone give me simple explanation.


I am unable to find the reply. Can anyone suggest me any site where I can make my self familiar with basic terminologies in molecular biology like 'deletion allele' :(

-Nabi-

well it means what it says.

Some alleles of genes are dues to short DNA sequence insertion and deletions into an exon.

Google this paper for an example
A 45-bp Insertion/Deletion Polymorphism of Uncoupling Protein 2 in Relation to Obesity in Tongans

-perneseblue-

Thank U pernesblue. Had come across other papers telling about deletion alleles of ACE in Japanese also. Wish could understand. Will try fresh tomorrow.

I was trying to understand what it meant by deletion allele and wild type allele in knockout mice.

-Nabi-