Protocol Online logo
Top : New Forum Archives (2009-): : -Genetics and Epigenetics-

Genexpression of overlapping genes - (Apr/06/2018 )

Hello everybody! 

 

I'm on the quest to find out why, when studying a certain gene, another gene is always being mentioned as well in it's expression. 

 

As it seems, the gene (MIR-6734) which always occurs when speaking of the main gene (ELOVL1), is sitting in the ELOVL1 gene, or is at least overlapping. (see file) 

 

Since I found no connection between the two genes in their function, but only in their localization, I assume the MIR gene is only mentioned because it is always expressed as well, when the ELOVL gene is being expressed. 

 

Does anyone have an idea why their expression seems to be coupled? Or why sometimes instead of the ELOVL1 gene, just the MIR6734 is mentioned, almost like synonyms for each other?

 

https://www.ncbi.nlm.nih.gov/gene?LinkName=geoprofiles_gene&from_uid=99233415

 

Thank you very much for ideas, infos and help! 


Attached Image

-Manaka-

Like we mentioned before the MIR-6734 is NOT a gene, it is a small interfering RNA and hence is not expressed, it is however, transcribed! It is not a synonym for ELOVL1 either. I suspect that because of the location in the coding sequence for ELOVL1, that it is transcribed at the same time as the ELOVL1 gene. 

 

If I were you I would be looking at mechanisms for miRNA transcription - it seems likely that these particular ones are coupled, and that this is a common mechanism.

-bob1-

Thank you very much for your help again! 

 

I'll surely do that! 

-Manaka-