Adult stem cells - (Jan/27/2014 )
I have a problem of concepts. I have been reading to understand the kind of cells that are nowadays being used in tissue engineering and when I try to break down Adult Stem Cells (ASCs) I get lose. Can anyone help me?
I understand that ASCs can be obtained from different sources (bone marrow, adipose tissue, endothelial tissue...). My misunderstanding arrives when I read about Mesenchymal stem cells. Are them a type of ASC? But they can also be obtained from different sources, aren't them?
Well probably trying to partition this is not possible, but I want to be sure not to have basic misconception.
Thanks you very much in advance for all the help you can give me
Wikipedia has a good article on this: http://en.wikipedia.org/wiki/Mesenchymal_stem_cell Words in biology are sometimes used by different people to have different meanings.
Mesenchymal stem cells are type of ASC, but can also be found in infants and children. You may be finding contradicting information out there as stem cell research in rapidly developing. New finding are published daily--some groups/people may have read/accept/believe/not accept/not believe them.
To add to the confusion, cells can also be "de-differentiated" to form more primitive multipotent stem cells. So if you are wondering if there is more than one way to get Mesenchymal stem cells from adult stem cells, the answer is a resounding yes! You can probably even move back and forth between the two.
If you are taking a specific class from a specific person, then whatever they say is right.
Who is the scientific team behind Bioheart?
Having an extreme interest in stem cell technology, the applications, the current benefits and the future milestones yet to be achieved, I’ve been looking more in depth into the companies who offer this incredible technology.
Doing some brief online searches about these companies, BioHeart (on the human side) and Stemlogix (on the animal side) appeared to be prominent in the public domain. I consistently came across news coverage, press releases and you tube videos about both companies and their success in the regenerative technology space.
Now being intrigued, I was more interested in the companies themselves, and not just the technology they offer, but the people behind making BioHeart and Stemlogix successful.
Doing more in depth research, and to much of my surprise, I came across a lawsuit filed by Stemlogix. What I learned from the allegations in this suit about management of what initially appeared to be quite reputable companies became even more concerning.
The lawsuit itself is filed by Stemlogix suing a scientist for breach of contract, whom they hired to create a scientifically validated method of controlled variables to yield a defined cell product to be used in training, research & cell banking.
Interestingly enough, this particular scientist whom they refer to is Kristen Comella, who is currently the Chief Science Officer of BioHeart and is also currently serving as co-founder and CEO of Stemlogix. Is this not a conflict in itself? Unless these are both part time positions, how can one person effectively manage these two roles?Additionally, I was also surprised to learn that Stemlogix is registered and operating out of Ms. Comella’s personal home address. How can a company offer “Premier In-Clinic Stem Cell Therapy Solutions for Veterinary Medicine” as stated on their website and be run from a person’s home?
However, some of the most interesting accusations of Ms. Comella outlined in this lawsuit are as follows:
- Stealing corporate funds by taking advances and moving financials out of the companies’ accounts.
- Misappropriation of trade secrets
- Misappropriated funds through Comella’s involvement with Pavillion Foods, a company owned and operated by Comella’s family, in which Comella insisted and insured that this “food company” be utilized as the sole source for lab kit materials and production of kits without seeking independent bidding for prices from third parties. (This particular point is a huge red flag to me, how is it safe, ethical and for the sake of quality control even logical to make stem cell kits in a food plant?)
- Disclosing confidential and proprietary business information to third parties, despite signed disclosure agreements and contracts
- Purposefully and intentionally withholding orders for stem cell kits and refusing to provide customer information to permit these orders be fulfilled in attempts to cause financial harm.
- Converting the day to day operations information of Ageless, Stemlogix and LabKits for her own personal use via improper hoarding of information.
It surprised me that a publicly traded company (BHRT) has managed to not only keep this under wraps but even have this individual employed, as her actions appear to be unethical and unbecoming of executive management of what again, I initially thought were two reputable companies.
I hope this prompts further action and response, as both these companies owe public investors and users of said technologies further explanation of how someone like this can be a part of their team and who actually stands behind their “science”.
For additional details and information regarding the full lawsuit, please see the following link: