Fanconi anaemia, how was the FANCA gene identified? - (Oct/24/2013 )
I've to do some research and makes notes on Fanconi anaemia.
I have to describe how the causative FANCA gene was identified and state what the protein does?
I have been using OMIM 227650, however i'm struggling to extract the required information. It says that its was first described in 1927 but i cant find what technique was used to determine the FANCA gene.
The structure of DNA wasn't described until 1953, so I seriously doubt that the gene was isolated before then... Fanconi described the condition in 1927, but the genetics will be much later.
Have a look at reference 8 in the references list...