difficulty in solubilizing L-cycloserine in water - (Dec/30/2012 )

Hi all !!!

I am facing difficulty in dissolving L-cycloserine in water. Manufacturer recommends to dissolve the antibiotic in water, and so does several research articles. But, I am not able to do so. Some literatures mention about dissolving the antibiotic in 1:9 ethanol. This method also did not solve my problem. Kindly help.


Thanks in advance

PVB

what concentration did you try to make? it is soluble to 25mg/ml in water.

Sorry for the delayed reply mdfenko

I am trying to make 25mg/ml concentration in water itself.


Thanks in advance
PVB

since you are trying to make the solution at the limit of solubility you will have to add water until it is at the final volume. then it should completely dissolve.

Dear Mr.mdfenko, 

Dear Mr.mdfenko, 

                     Cycloserine is easily soluble in DMSO.