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Sample size determination - (Oct/29/2012 )

Hai All,
Could anyone explain me how the sample size for a clinical study is determined?
Thanks in advance.
Bless

-Blessbio-

that's a very broad question. what are you working on?

-Curtis-

Well, i am planning to do a study in allergy but i have to decide the sample size and i have no idea how to do it

-Blessbio-