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what will happen if you let your affinity column beads dry? - (Aug/07/2012 )

does anyone know what will really happen? I know that it's going to wreck the column, but what does actually happen? thanks

-rock&science-

depends on the beads...

can cause breakage leading to "fines" which will interfere with the flow of mobile phase (the technical term is "clog the column")

-mdfenko-