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Opinions wanted - What is needed to design enzymes capable of the rate enhanceme - (Apr/24/2011 )

Wanted discussions on how enzymes reach 10^16+ rate increases and what can be done to design enzymes with similar rate increases.

I'll start the discussion by saying that I don't believe transition state stabilization results in the bulk of the rate increase in enzyme catalysis.

-jerseysurfer66-

jerseysurfer66 on Sun Apr 24 18:36:55 2011 said:


Wanted discussions on how enzymes reach 10^16+ rate increases and what can be done to design enzymes with similar rate increases.

I'll start the discussion by saying that I don't believe transition state stabilization results in the bulk of the rate increase in enzyme catalysis.


How can we design our own enzymes?
For starters, we need to gather ~1 trillion more years in man hours worth of research...

-Kaioshin-

Agree on that we need much more research but highly doubtful a trillion years is necessary. This is a next 10 year development.

-jerseysurfer66-

jerseysurfer66 on Mon Apr 25 03:23:09 2011 said:


Agree on that we need much more research but highly doubtful a trillion years is necessary. This is a next 10 year development.


You should probably look up the definition of "man hours"

-Kaioshin-

U should try and understand the number "a trillion" .

-jerseysurfer66-