ATP turnover in neuron - ATP hydrolysis rates in neuronal cells (May/26/2010 )

Dear all,

I am trying to model energy metabolism in a neuron. Could anyone give me references about ATP turnover in neurons (data or estimated values)?
I found a paper (Actin-ATP Hydrolysis Is a Major Energy Drain for Neurons; Bernstein&Bamburg) which states that Actin is the major energy consumer in the neuron, but maintaining the membrane potential should consume energy as well.
Does anybody know if ATP hydrolysis occurs peakwise in neurons?
Any help would be appreciated!

Thanks in advance,

Hannes

capybara! on May 26 2010, 10:30 AM said:

I think the ATP consumption of a neuron depends on its status (growing, stimulated, firing etc);

what do you mean by peakwise? Do you think of the whole cell or of local events?

Hi, thank you for your answer!

I mean a whole cell. In resting state, there should be less energy consumed than if the neuron is excited and fires its synapses.
But does the neuron, if it gets enough depolarized, fire all its synapses at the same time? This would then mean that at or shortly after the firing of the
synapses, there should be more energy consumed than in the 'normal' state.

I try to model a neuron's energy metabolism over time; let's say we simulate a condition in which the neuron fires its synapses once every second.
For this I need a function which describes the energy consumption of the neuron. My question is, if I can assume that this function has an oscillatory
behavior over time given a (regular) firing pattern.

I did find values in the literature for ATP consumption in brain (i.e. 80 micromol/l/s), but what I am trying to find are values for ATP consumption in resting state
and in firing state. So basically I want to know if there is oscillation in ATP consumption, and if so, how high would the amplitude be?

Regards

Hannes