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Question on wired PCR - (Jan/12/2010 )

Dear all,
I am here to ask a strange PCR result? I do one multi-plex PCR with bioline enzyme. I use 94 degree to denature the DNA. The results I got is very strange. I always can see a big smear smear from the DNA loading well to DNA ladder 2 kb position. I don't how this things happens.
Maybe some one you here can give me some adivce to give ride of it. I have used the same template to do another PCR and the results are very specific.
Thanks you all in advance and happy new year. :o
Attached you can see how the picture looks like.
Attached Image


Do you experience such incident when individual primer pairs from the multiplex were used?

-adrian kohsf-