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Fas death receptor inhibitor - (Oct/19/2009 )

Greetings,

Does anyone know a small molecule inhibitor for Fas (a cell death receptor) and where can I order it from? I need it to inhibit Fas signaling for cells in culture.

Thanks

Pmaj:-)

-pmaj-

pmaj on Oct 19 2009, 07:39 PM said:

Greetings,

Does anyone know a small molecule inhibitor for Fas (a cell death receptor) and where can I order it from? I need it to inhibit Fas signaling for cells in culture.

Thanks

Pmaj:-)


You could use antibodies against Fas receptor or Fas ligand:

the neutralizing antibody against the FAS-receptor (5 g in phosphate-buffered saline; clone ZB4; Upstate Biotechnology, Lake Placid, NY) or FAS-ligand (5 g in phosphate-buffered saline; clone NOK-1; BD Biosciences)

and also you could use inhibitor of caspase-8.

-blotted-

You could try knocking down the Fas... though it would add quite a bit of complexity to the experiments.

-bob1-