Immunology - Do MHC I ligands occur on CD4+ and CD8+ T-cells? (Oct/05/2009 )
It is generally understood that MHC class I ligands occur virtually on all nucleated cells? CD4+ and CD8+ T-cells being classified as nucleated cells must therefore, constitutively express MHC-I ligands? Do they express MHC-I ligand and indeed present peptides to other naive specific CD8+ T-cells that sample these cells?
CellSpecific.com on Oct 5 2009, 06:48 AM said:
Thank you for your time! But I was wondering if CD4+ and CD8+ T-cells possessed the ability to present peptide antigens (if they possessed MHC I ligands as they too are nucleated cells inasmuch as virtually any nucleated cells must have surface MHC I ligand 'happily' expressed!!!) to prime peptide specific naive CD8+ T-cells!
Hope now you are pretty clear with my question!
CellSpecific.com on Oct 5 2009, 06:46 AM said:
Thanks for this post sir..i am highly obliged for this post... APC pocesses both MHC class I and class II molecule... these are histone complexes in nature and i think total 4 classes are there.. am i right?
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