Protocol Online logo
Top : New Forum Archives (2009-): : General Biology Discussion

virus-like particles - where to find info or book? (Sep/11/2009 )

i need to give a presentation next week and want to find some info about VLP's.

do you know any good book or website to have enough info, techniques, history etc.?

thanks in advance

-Curtis-

here is just one of the websites i found by googling "virus-like particles":

novavax

and this wikipedia page has some linked references:

wikipedia: virus-like particles

-mdfenko-

Groan - come on, this is a science forum. Please, let's not cite soemthing as unreliable as Wikipedia.

see below:

Mol Plant Pathol. 2009 Jan;10(1):115-28. Links
Mycoviruses of filamentous fungi and their relevance to plant pathology.Pearson MN, Beever RE, Boine B, Arthur K.
School of Biological Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand. m.pearson@auckland.ac.nz

Mycoviruses (fungal viruses) are reviewed with emphasis on plant pathogenic fungi. Based on the presence of virus-like particles and unencapsidated dsRNAs, mycoviruses are common in all major fungal groups. Over 80 mycovirus species have been officially recognized from ten virus families, but a paucity of nucleic acid sequence data makes assignment of many reported mycoviruses difficult. Although most of the particle types recognized to date are isometric, a variety of morphologies have been found and, additionally, many apparently unencapsidated dsRNAs have been reported. Until recently, most characterized mycoviruses have dsRNA genomes, but ssRNA mycoviruses now constitute about one-third of the total. Two hypotheses for the origin of mycoviruses of plant pathogens are discussed: the first that they are of unknown but ancient origin and have coevolved along with their hosts, the second that they have relatively recently moved from a fungal plant host into the fungus. Although mycoviruses are typically readily transmitted through asexual spores, transmission through sexual spores varies with the host fungus. Evidence for natural horizontal transmission has been found. Typically, mycoviruses are apparently symptomless (cryptic) but beneficial effects on the host fungus have been reported. Of more practical interest to plant pathologists are those viruses that confer a hypovirulent phenotype, and the scope for using such viruses as biocontrol agents is reviewed. New tools are being developed based on host genome studies that will help to address the intellectual challenge of understanding the fungal-virus interactions and the practical challenge of manipulating this relationship to develop novel biocontrol agents for important plant pathogens.

-GeorgeWolff-

thank you guys

-Curtis-

GeorgeWolff on Sep 23 2009, 06:26 PM said:

Groan - come on, this is a science forum. Please, let's not cite soemthing as unreliable as Wikipedia.

georgewolff,

if you read my post you will see that i recommended the wikipedia page for the references cited, not as the "tell-all".

by the way, i find that wikipedia is not a bad place for a student to start, as long as it is not the only place they look. many of the references are valid and good.

not everything in wikipedia is trash. it is just a general encyclopedia written with the lowest common denominator in mind. in other words, a starting point.

-mdfenko-

I agree with mdfenko

-Curtis-

Me too.

I found that paper via wikipedia (german), perhaps it's helpful:

E.V. Grgacic und D.A. Anderson: Virus-like particles: passport to immune recognition. In Methods. 2006 Sep;40(1):60-5.
Pubmed-link

-hobglobin-