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Latest Scientific Breakthroughs

Articles in Press from Science, Nature, Cell and the Lancet. Updated daily
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Nature - Advance Online Publication (AOP)
• Biogeochemistry: Food for early animal evolution (Nature, 2017-08-16)
• Biochemistry: A toxin that fuels metabolism (Nature, 2017-08-16)
• Global health: Probiotic prevents infections in newborns (Nature, 2017-08-16)
• Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism (Nature, 2017-08-16)
• A randomized synbiotic trial to prevent sepsis among infants in rural India (Nature, 2017-08-16)
• The primed SNARE–complexin–synaptotagmin complex for neuronal exocytosis (Nature, 2017-08-16)
• The rise of algae in Cryogenian oceans and the emergence of animals (Nature, 2017-08-16)
• CMTM6 maintains the expression of PD-L1 and regulates anti-tumour immunity (Nature, 2017-08-16)
• CDK4/6 inhibition triggers anti-tumour immunity (Nature, 2017-08-16)
• Mechanism of intracellular allosteric β2AR antagonist revealed by X-ray crystal structure (Nature, 2017-08-16)
• Identification of CMTM6 and CMTM4 as PD-L1 protein regulators (Nature, 2017-08-16)
Nature477 -
• Particle physics: No sign of asymmetry in the strong force (Nature477 , 2017-06-14)
Nature478 -
• 50 & 100 Years Ago (Nature478 , 2017-06-21)
Nature Genetics - Advance Online Publication (AOP)
• Mutations in KEOPS-complex genes cause nephrotic syndrome with primary microcephaly (Nature Genetics, 2017-08-14)
• Lineage-specific dynamic and pre-established enhancer–promoter contacts cooperate in terminal differentiation (Nature Genetics, 2017-08-14)
• Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn's disease (Nature Genetics, 2017-08-14)
• Classification of common human diseases derived from shared genetic and environmental determinants (Nature Genetics, 2017-08-07)
• Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration (Nature Genetics, 2017-08-07)
• TMPRSS2–ERG fusion co-opts master transcription factors and activates NOTCH signaling in primary prostate cancer (Nature Genetics, 2017-08-07)
• Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability (Nature Genetics, 2017-08-07)
• A common intronic variant of PARP1 confers melanoma risk and mediates melanocyte growth via regulation of MITF (Nature Genetics, 2017-07-31)
Science - Sciencexpress
• Mutations in the promoter of the telomerase gene TERT contribute to tumorigenesis by a two-step mechanism (Science, )
• The turbulent cascade in five dimensions (Science, )
• Dynamic multinuclear sites formed by mobilized copper ions in NOx selective catalytic reduction (Science, )
• DNA replication-coupled histone modification maintains Polycomb gene silencing in plants (Science, )
• Distinct phases of Polycomb silencing to hold epigenetic memory of cold in Arabidopsis (Science, )
• Fertile offspring from sterile sex chromosome trisomic mice (Science, )
• Hydrogenation of fluoroarenes: Direct access to all-cis-(multi)fluorinated cycloalkanes (Science, )
• Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 (Science, )
• Global mRNA polarization regulates translation efficiency in the intestinal epithelium (Science, )
• Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function (Science, )
• mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation (Science, )