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Spook

Member Since 27 Jul 2012
Offline Last Active Dec 26 2012 03:47 PM

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Pharmaceutical Sciences, ADMET, Drug Disposition, Safety Assessment

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Julio-Claudian
27 Jul 2012 - 09:40

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Inhibition P450 BM3 FAD/NADPH domain?

27 July 2012 - 09:18 AM

Hi,

I'm doing some research on CYP P450 BM3, but I am wondering why all inhibitors act on the heme group. Isn't it also possible to inhibit the FAD/NADPH domain by an inhibitor that competes with NADPH for binding to the FAD so that NADPH, the cofactor, can not bind and thus it can not act as a monooxygenase?