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DDLJ

Member Since 31 Dec 2011
Offline Last Active Feb 19 2012 12:58 PM

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NTTH
12 Jan 2012 - 03:56
Trof
06 Jan 2012 - 12:52
Felipillo
01 Jan 2012 - 21:31
merinator
31 Dec 2011 - 07:19

#127306 What is the difference between Polymorphism and SNP

Posted pito on 18 January 2012 - 11:29 PM

DDLJ, on 31 December 2011 - 08:50 AM, said:

But it is becoz of polymorphism only, each individual differ from each other, then how polymorphism contributing to diseases.

1. SNP is a type of polymorphism
2. polymorphism just means that the DNA is "different" due to a mutation for example, a base switch (T and not G for example at a certain place)
3. I think its clear that when you normally have GATC and due to a SNP you have all of a sudden AATC that this change in sequence can cause a disease..
(another example: take for example a SNP in a gene coding for a protein and because of this SNP you get a stop codon rather then a codon for an AA , then what happens? translation will stop and you will not form that protein.. result: disease (or not, its not always the worst case scenario ofcourse)

And that paper might help indeed.

#126543 qRTPCR using taqman

Posted Trof on 05 January 2012 - 02:02 PM

Try to find something about primer and probe design and then use design software like Primer Express (you should have it if you have ABI machine) , or free aplication like primer3.

#126362 Chemical elements present in fungi

Posted Phil Geis on 03 January 2012 - 01:44 PM

Think hobglobin makes the point. The same macro/microelements Na, K, Ca, Zn, Fe, Mg, Mn, prob some Cu with environment influencing relative levels. For example, I'm aware that some fungi accumulate Ca and K if grown under high saline conditions Environment drives others for example V, Cd, As if present in the imediate environment.
Here's a recent article you can use for its data and references - http://www.ncbi.nlm....pubmed/21091259