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Tufy

Member Since 21 Apr 2011
Offline Last Active Jan 02 2013 10:08 AM

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#143636 An assay for testing general chromatin compaction???

Posted Tufy on 18 October 2012 - 07:43 AM

Hi,

I would like to test if the global level of chromatin compaction in the cells of interest changes after a treatment. I know that you can use MNase for a specific genomic location, but what if you'd like to see if there is any global effect? Is it possible to couple MNase with WB or any other method to get the answer to this? Or are the only alternatives sequencing-based methods (eg MNase-seq, FAIRE-seq)?

Many thanks!