i have to use 1% methyl cellulose as a vehicle for Prednisone injections.
the vehicle is made of water+ 0.9% NaCl+ 1% Methyl Cellulose.
when i've tried to just add the methyl cellulose to a saline solution it didn't dissolve good and there were a lot of clumps.
right now i've tried to prepare the solution by:
1) warm a Saline solution to 65C and then to add the Methyl Cellulose.
2) then to cool it down by attach the tube to a Vortex and shake it in a 8C room for 20Min, or until it cooled down.
there were no clumps, but the problem is that there was a lot of foam in the tube.
Iv'e found another protocols but they require to shake it, but the shaking makes a lot foam, or that they require to freeze the solution for a long time before the use.
Edited by megashock, 12 July 2009 - 05:52 AM.