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Anti-HCC drug


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#1 Dr_Mai

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Posted 13 June 2009 - 11:54 AM

Dear all,
I'm currently working on hepatocellular carcinoma cells (HuH-7); testing the effect of an anticancer drug..
but I'm looking for a positive control to compare my results with...

Please tell me if you know any! (favorably affecting the p53 expression in p53-transfected cells.)

Thanks

#2 yobou

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Posted 14 June 2009 - 01:12 AM

cytotoxic drugs like doxorubicin is fine

#3 Dr_Mai

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Posted 14 June 2009 - 11:14 AM

cytotoxic drugs like doxorubicin is fine



Thanks yobou, but doxorubicin acts through inhibiting topoisomerase enzyme and inhibiting DNA unwinding...
but i'm looking for a pro-apoptotic drug that acts through up-regulation of p53 tumor suppressor gene..


Thanks :-|

#4 yobou

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Posted 14 June 2009 - 08:42 PM

you said in your post (favorably affecting the p53 expression ).
The relationship between DNA damge, G2-M arrest and activation of p53 is very well documented. if you write (doxorubicin-induced p53 activation ) on the pubmed or google you will get many reports

Edited by yobou, 14 June 2009 - 08:52 PM.


#5 Dr_Mai

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Posted 15 June 2009 - 11:35 PM

Thanks yobou




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