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Plant biotech

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#1 Jon Moulton

Jon Moulton


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Posted 09 June 2009 - 12:53 PM


d'Erfurth I, Jolivet S, Froger N, Catrice O, Novatchkova M, et al. (2009) Turning Meiosis into Mitosis. PLoS Biol 7(6): e1000124. doi:10.1371/journal.pbio.1000124


If knockdown of OSD1 is sufficient to cause the meiosis-to-mitosis conversion, then treatment of germline cells with antisense oligos might provide a method for making single-generation clones. If viable seeds are produced from treated germline cells, the clones can be sold -- but without the oligo treatment, they will only reproduce sexually. This could be a great commercial advantage.

Here is a potential tool for this process: Morpholino oligos can transiently knock down genes in plants.

Okuda S, Tsutsui H, Shiina K, Sprunck S, Takeuchi H, Yui R, Kasahara RD, Hamamura Y, Mizukami A, Susaki D, Kawano N, Sakakibara T, Namiki S, Itoh K, Otsuka K, Matsuzaki M, Nozaki H, Kuroiwa T, Nakano A, Kanaoka MM, Dresselhaus T, Sasaki N, Higashiyama T. Defensin-like polypeptide LUREs are pollen tube attractants secreted from synergid cells. Nature. 2009 Mar 19;458(7236):357-61.
Jon D. Moulton
Gene Tools, LLC

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