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genome annotation


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#1 dersven

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Posted 04 June 2009 - 12:07 AM

HI!
I have genomic sequences of a human chromosome, and like to annotate it. Since there might be structural variants I can't simply use the positions provided e.g. by ensemble databases. I thought doing a BLAST-search, but I'm not sure if this is the right way, since the genomic DNA contains the introns.
How are those things usually done on a large scale?
Should I only use the exons as a query?

Thanks for your help.

#2 cellcounter

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Posted 26 June 2009 - 09:36 AM

HI!
I have genomic sequences of a human chromosome, and like to annotate it. Since there might be structural variants I can't simply use the positions provided e.g. by ensemble databases. I thought doing a BLAST-search, but I'm not sure if this is the right way, since the genomic DNA contains the introns.
How are those things usually done on a large scale?
Should I only use the exons as a query?

Thanks for your help.

You may want to check out some genome annotation tools or powerpoints search results to see how this is done.




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