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Bare morpholino dosing regimens compared in mdx mice

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#1 Jon Moulton

Jon Moulton


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Posted 28 May 2009 - 10:41 AM

Splice modifying oligos: repeated small doses of unmodified Morpholinos are found to increase dystrophin expression more effectively than single large doses when administered to mdx mice.

Malerba A, Thorogood FC, Dickson G, Graham IR. Dosing regimen has a significant impact on the efficiency of morpholino oligomer-induced exon skipping in mdx mice. Hum Gene Ther. 2009 May 26. [Epub ahead of print]
Jon D. Moulton
Gene Tools, LLC

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