Splice modifying oligos: repeated small doses of unmodified Morpholinos are found to increase dystrophin expression more effectively than single large doses when administered to mdx mice.
Malerba A, Thorogood FC, Dickson G, Graham IR. Dosing regimen has a significant impact on the efficiency of morpholino oligomer-induced exon skipping in mdx mice. Hum Gene Ther. 2009 May 26. [Epub ahead of print]
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Posted 28 May 2009 - 10:41 AM
Jon D. Moulton
Gene Tools, LLC
www.gene-tools.com
Gene Tools, LLC
www.gene-tools.com
