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heat maps

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#1 SF_HK



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Posted 24 May 2009 - 06:29 PM


Can anyone suggest a website, book or paper which explains hows to read/understand a heat map. I have been asked to read on this topic. Each cells in a heat map represents the expresison of a gene and teh expression intensity is colour coded e.g. red for high expresison etc. But my main cincern is that when peope publish a heatmap, all teh reader see's a bock of red,yello and green colours. It doens[t show eh name of a gene etc does it?

#2 warsel



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Posted 27 May 2009 - 07:19 AM

Usually heatmaps are presented to show patterns of genes being regulated.

This means that showing each and every name would be very cumbersome, instead you show genes from a given pathway or with similar Gene Ontology (GO) terms.

So, as an example, if I would like to show that a given drug causes DNA damage in my cells I could look for genes in the p53 pathway and look at their expression pattern.

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