Can some one tell me how Can i look into the signalling cascade for Src kinase activation and its further downstream pathways.
Is there any online database. I will appreciate for your help.
regards
0
2 replies to this topic
#2
-
- Active Members
-
- 176 posts
Veteran
Posted 24 April 2009 - 08:27 AM
Millipore has an area online with schematics of around 250 biological pathways. They may or may not have the pathway you're looking for, but it's worth a shot. Heres a link:
http://www.millipore...ays/pw/pathways
http://www.millipore...ays/pw/pathways
Above all things, if kindness is your king,
then heaven will be yours, before you meet your end
then heaven will be yours, before you meet your end
#3
-
- Members
-
- 3 posts
member
Posted 08 February 2012 - 02:57 AM
SRC plays an important role in both receptor-tyrosine-kinase-mediated proliferation and transformation of the cell to a tumor phenotype. Src is phosphorylated and activated by the growth factors binding to growth factor receptors including VEGFR, PDGFR, c-met receptors, ErbB family receptors and interleukin 6 (IL-6) receptors. Activated SRC transduces a signal via phosphorylation of the adaptor protein Shc to the cascade that involves Ras and theMAPK family member, extracellular regulated kinase (Erk). This induces transcription of the early gene c-myc and increases DNA synthesis. SRC can activate STAT3 via SRC and Erk kinase and induce cell transformation.
