2 replies to this topic

[samita]

Can some one tell me how Can i look into the signalling cascade for Src kinase activation and its further downstream pathways.
Is there any online database. I will appreciate for your help.
regards

[gfischer]

Millipore has an area online with schematics of around 250 biological pathways.  They may or may not have the pathway you're looking for, but it's worth a shot.  Heres a link:
http://www.millipore...ays/pw/pathways

[tracyzh130]

SRC plays an important role in both receptor-tyrosine-kinase-mediated proliferation and transformation of the cell to a tumor phenotype. Src is phosphorylated and activated by the growth factors binding to growth factor receptors including VEGFR, PDGFR, c-met receptors, ErbB family receptors and interleukin 6 (IL-6) receptors. Activated SRC transduces a signal via phosphorylation of the adaptor protein Shc to the cascade that involves Ras and theMAPK family member, extracellular regulated kinase (Erk). This induces transcription of the early gene c-myc and increases DNA synthesis. SRC can activate STAT3 via SRC and Erk kinase and induce cell transformation.