SRC plays an important role in both receptor-tyrosine-kinase-mediated proliferation and transformation of the cell to a tumor phenotyp
hosphorylated and activated by the growth factors binding to growth factor receptors including VEGFR, PDGFR, c-met receptors, ErbB family receptors and interleukin 6 (IL-6) receptors. Activated SRC transduces a signal via phosphorylation of the adaptor protein Shc to the cascade that involves Ras and theMAPK
family member, extracellular regulated kinase (Erk). This induces transcription of the early gene c-myc and increases DNA synthesis. SRC can activate STAT
3 via SRC and Erk kinase and induce cell transformation.