Conjugation of Morpholino antisense oligos with endosomal escape moieties is bringing effective antisense techniques to rodent research. Such conjugates will likely debut soon as therapeutics. This is an open-access review of two delivery-enabled forms of Morpholinos.
Moulton JD, Jiang S. Gene Knockdowns in Adult Animals: PPMOs and Vivo-Morpholinos. Molecules. 2009; 14(3):1304-1323.
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Jon Moulton
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Posted 25 March 2009 - 12:27 PM
Jon D. Moulton
Gene Tools, LLC
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Gene Tools, LLC
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