How adjacent or remote CpG affects expression?
Posted 25 March 2009 - 09:27 AM
If the CpG island is not overlapping with Promoter region, But if it is adjacent to the promoter, then how does it affect gene expression? By binding to some proteins?
If CpG island is remote, then does it matter?
Reference to any paper will be appreciated. I am alos looking into.
Posted 31 March 2009 - 08:32 PM
Posted 01 April 2009 - 08:49 AM
Posted 01 April 2009 - 10:00 AM
thanks to all of you,
Methylated CpG islands can also recruit chromatin remodelling proteins. These islands probably do not have to be in the promoter region to have an effect.
But i could not find out any paper where they mentioned explicitly how the CpG island which is remote from promoter is affecting.
Got one paper where they said short sequence of CG residues in promoter can act with remote CpG island. But how they did not mention.
Posted 02 April 2009 - 01:54 PM
Posted 06 April 2009 - 06:22 AM
H19/IGF are the prime examples of this and the binding of CTCF in a methylation dependent manner, this binding region is a CpG island and it can effect the expression of a gene remote from it.
thanks Nick, it was really helpful to find out the answer of my question.