Jump to content

  • Log in with Facebook Log in with Twitter Log in with Windows Live Log In with Google      Sign In   
  • Create Account

Submit your paper to J Biol Methods today!
Photo
- - - - -

cyclodextrin


  • Please log in to reply
4 replies to this topic

#1 dharmani

dharmani

    member

  • Active Members
  • Pip
  • 7 posts
0
Neutral

Posted 13 March 2009 - 01:04 AM

Hai, i was recently was asked to work with beta-cyclodextrin to dissolve a compound as this compound does not dissolve in water, DMSO or tween 20. I

In the MSDS of beta-cyclodextrin, there is no mention on how it can be dissolved.
I have tried dissolving it in water, but it didn't work.
Has anyone used cyclodextrin before. Please suggest to me how to dissolve it?

Thanks

#2 klinmed

klinmed

    Veteran

  • Active Members
  • PipPipPipPipPipPipPipPipPipPip
  • 209 posts
1
Neutral

Posted 13 March 2009 - 02:42 AM

Hai, i was recently was asked to work with beta-cyclodextrin to dissolve a compound as this compound does not dissolve in water, DMSO or tween 20. I

In the MSDS of beta-cyclodextrin, there is no mention on how it can be dissolved.
I have tried dissolving it in water, but it didn't work.
Has anyone used cyclodextrin before. Please suggest to me how to dissolve it?

Thanks


Beta-cyclodextrin is sparingly soluble in hot water but can be dissolved easily in 1M NaOH. Can you use the derivative hydroxypropyl-β-cyclodextrin (HBC) which is soluble at > 50 mg/ml in water? HBC is extensively used to "solubilize" lipophilic drugs and has replaced cyclodextrin in many pharmaceutical processes.

Hope this helps.

#3 phage434

phage434

    Veteran

  • Global Moderators
  • PipPipPipPipPipPipPipPipPipPip
  • 2,442 posts
242
Excellent

Posted 15 March 2009 - 04:30 PM

Does cyclodextrin come out of solution if the NaOH is neutralized?

#4 molgen

molgen

    Veteran

  • Active Members
  • PipPipPipPipPipPipPipPipPipPip
  • 167 posts
0
Neutral

Posted 15 March 2009 - 11:41 PM

Molecular properties related to the anomalous solubility of beta-cyclodextrin

#5 dharmani

dharmani

    member

  • Active Members
  • Pip
  • 7 posts
0
Neutral

Posted 16 March 2009 - 01:10 AM

Hai, i was recently was asked to work with beta-cyclodextrin to dissolve a compound as this compound does not dissolve in water, DMSO or tween 20. I

In the MSDS of beta-cyclodextrin, there is no mention on how it can be dissolved.
I have tried dissolving it in water, but it didn't work.
Has anyone used cyclodextrin before. Please suggest to me how to dissolve it?

Thanks


Beta-cyclodextrin is sparingly soluble in hot water but can be dissolved easily in 1M NaOH. Can you use the derivative hydroxypropyl-β-cyclodextrin (HBC) which is soluble at > 50 mg/ml in water? HBC is extensively used to "solubilize" lipophilic drugs and has replaced cyclodextrin in many pharmaceutical processes.

Hope this helps.



Thanks for the info. I will give this a try.




Home - About - Terms of Service - Privacy - Contact Us

©1999-2013 Protocol Online, All rights reserved.