Warning: mb_substr_count() expects at most 3 parameters, 4 given in /home/protocol/public_html/forums/admin/sources/classes/text/parser/bbcode/defaults.php on line 1269

Warning: Cannot modify header information - headers already sent by (output started at /home/protocol/public_html/forums/admin/sources/classes/text/parser/bbcode/defaults.php:1269) in /home/protocol/public_html/forums/admin/sources/classes/output/formats/html/htmlOutput.php on line 110

Warning: Cannot modify header information - headers already sent by (output started at /home/protocol/public_html/forums/admin/sources/classes/text/parser/bbcode/defaults.php:1269) in /home/protocol/public_html/forums/admin/sources/classes/output/formats/html/htmlOutput.php on line 127

Warning: Cannot modify header information - headers already sent by (output started at /home/protocol/public_html/forums/admin/sources/classes/text/parser/bbcode/defaults.php:1269) in /home/protocol/public_html/forums/admin/sources/classes/output/formats/html/htmlOutput.php on line 136

Warning: Cannot modify header information - headers already sent by (output started at /home/protocol/public_html/forums/admin/sources/classes/text/parser/bbcode/defaults.php:1269) in /home/protocol/public_html/forums/admin/sources/classes/output/formats/html/htmlOutput.php on line 137

Warning: Cannot modify header information - headers already sent by (output started at /home/protocol/public_html/forums/admin/sources/classes/text/parser/bbcode/defaults.php:1269) in /home/protocol/public_html/forums/admin/sources/classes/output/formats/html/htmlOutput.php on line 141
Antisense delivery in adult mice - Animal and Zoology - BioForum

Jump to content

  • Log in with Facebook Log in with Twitter Log in with Windows Live Log In with Google      Sign In   
  • Create Account

Submit your paper to J Biol Methods today!
Photo
- - - - -

Antisense delivery in adult mice


  • Please log in to reply
No replies to this topic

#1 Jon Moulton

Jon Moulton

    Veteran

  • Active Members
  • PipPipPipPipPipPipPipPipPipPip
  • 145 posts
3
Neutral

Posted 10 March 2009 - 10:20 AM

Vivo-Morpholinos used in a mouse model of Duchenne muscular dystrophy:
Wu B, Li YF, Morcos PA, Doran TJ, Lu PJ and Lu QL. Octa-guanidine Morpholino Restores Dystrophin Expression in Cardiac and Skeletal Muscles and Ameliorates Pathology in Dystrophic mdx Mice. Mol. Ther. advance online publication, March 10, 2009

http://www.nature.co.../mt200938a.html

Dystrophin exon 23 carries a nonsense mutation in the mdx mouse. Using a Morpholino oligo targeting an exon 23 splice junction can cause the splice machinery to skip exon 23, allowing translation of functional dystrophin with an internal deletion; however, unmodified Morpholinos enter cells poorly and large doses must be used to achieve splice modification in the mouse tissues. Coupling a Morpholino to a guanidinium dendrimer moiety makes a Vivo-Morpholino. When injected into the blood the Vivo-Morpholino circulates through the organism and enter cells, altering splicing and producing functional dystrophin.
Jon D. Moulton
Gene Tools, LLC
www.gene-tools.com




Home - About - Terms of Service - Privacy - Contact Us

©1999-2013 Protocol Online, All rights reserved.